Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance
نویسندگان
چکیده
منابع مشابه
Cortisol Metabolism
Cortisol is the principal glucocorticoid hormone in humans, contributing to homeostatic regulation of basal metabolism and salt and water balance, and modulating the response to stress. Normal adult human adrenal glands secrete around 5—15mg per day of cortisol. Only a small fraction is excreted as free cortisol in urine, saliva or bile. The rest is cleared by several metabolic pathways before ...
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The production and peripheral metabolism of cortisol have been studied in 10 cirrhotics and 11 controls after i.v. tracers of cortisol-(14)C. The findings were as follows: (a) Total urinary excretion of radioactivity was normal (81% of the dose) but a decreased fraction was present as glucosiduronates: 18-47% of the dose (average 34%) compared to a normal average of 54%. (b) There was a distinc...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2002
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2002-020048